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A prospective study was done to observe electrocardiographic changes induced by water-soluble contrast media during routine intravenous pyelography. Among total 161 patients, 71 patients were received Meglumine/Sodium Diatrizoate(Diatrizoate group), 60 patients were received Meglumine Iodamide(Iodamide group), and 30 patients were received 5% D/W solution(Control group). Intravenous injections were made in speed of 0.18ml per second in all patients including control group. Changes of heart rates and rhythms were monitored with Holter Recorder before, during and after injection, for 5 minutes, 2 minutes and 5 minutes each. The results were as follows: 1. In preinjection state, the heart rates were 73.5±8.8/Min. in control group, 73.8±9.7/Min. in Diatrizoate group, and 75.4±10.4 in Iodamide group, respectively. 2. In postinjection state, the heart rates were changed to 75.8±9.9 in control group, 82.6±14.5 in Diatrizoate group, and 83.4±12.4 in Iodamine group, respectively. The changes of the heart rates were interpreted as a significant increase in Diatrizoate group and Iodamide group(p＜0.001), while in control group the changes were interpreted as an insignificant increase(p＞0.05). There was no significant difference between Diatrizoate group and Iodamide group. 3. Increase of the heart rates more than 10 beats per minute were observed in 17/71(23.9%) in Diatrizoate group and 12/60(20.0%) in Iodamide. In control group, one patient showed increase of the heart rates more than 10 beats per minute. 4. In preinjection state, only two patients showed abnormal heart rhythm, one each in Diatrizoate group and Iodamide group. In postinjection state, 9 patients showed abnormal heart rhythm, 6 in Diatrizoate group(8.6%) and 3 in Iodamide group(5.0%). No one in control group showed abnormal rhythm either in pre or post injection state. 5. The average age of patients who showed no abnormal rhythm after injection was 40.0 years, while the average age of the patients who showed abnormal rhythm after injection was 55.9 years.
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